Kombiglyze Xr

Careful follow-up of weight and height in children ages 7 to 10 years who were randomized to either methylphenidate or non-medication treatment groups over 14 months, as well as in naturalistic subgroups of newly methylphenidate-treated and non-medication treated children over 36 months (to the ages of 10 to 13 years), suggests that consistently medicated children (i.e., treatment for 7 days per week throughout the year) have a temporary slowing in growth rate (on average, a total of about 2 cm less growth in height and 2.7 kg less growth in weight over 3 years), without evidence of growth rebound during this period of development.

Published data are inadequate to determine whether chronic use of amphetamines may cause a similar suppression of growth, however, it is anticipated that they will likely have this effect as well. Therefore, growth should be monitored during treatment with stimulants, and patients who are not growing or gaining weight as expected may need to have their treatment interrupted.

There is some clinical evidence that stimulants may lower the convulsive threshold in patients with prior history of seizure, in patients with prior EEG abnormalities in absence of seizures, and very rarely, in patients without a history of seizures and no prior EEG evidence of seizures. In the presence of seizures, the drug should be discontinued.

用于治疗ADHD的刺激剂，包括右旋苯丙胺糖，苯丙胺天冬氨酸，右旋苯丙胺硫酸盐和二苯丙胺硫酸盐片，与包括Raynaud的现象有关。体征和症状通常是间歇性和温和的；但是，非常罕见的后遗症包括数字溃疡和/或软组织破裂。在整个治疗过程中，在不同时间和所有年龄段的治疗剂量的市场报告中都观察到外周外周血管病的影响，包括雷诺现象。药物剂量或停用后，症状和症状通常会改善。在使用ADHD兴奋剂治疗期间，必须仔细观察数字变化。进一步的临床评估（例如，风湿病转诊）可能适合某些患者。

注意力缺陷多动障碍（ADHD; DSM-IV®）的诊断意味着存在导致损害并在7岁之前出现的过度活跃的冲动或注意力不集中症状。这些症状必须在社会，学术或职业功能中引起临床上的显着障碍，并在两个或多个环境中存在，例如学校（或工作）和家里。另一种精神障碍不得更好地解释症状。对于不专心的类型，至少六个症状必须持续至少6个月：缺乏对细节/粗心的错误的关注；缺乏持续的关注；可怜的听众；未能遵循任务；组织差；避免需要持续精神努力的任务；失去东西； easily distracted; forgetful. For the Hyperactive-Impulsive Type, at least six of the following symptoms must have persisted for at least 6 months: fidgeting/squirming; leaving seat; inappropriate running/climbing; difficulty with quiet activities; "on the go;" excessive talking; blurting answers; can't wait turn; intrusive. The Combined Type requires both inattentive and hyperactive-impulsive criteria to be met.

特定的这种综合征的病因尚不清楚,there is no single diagnostic test. Adequate diagnosis requires the use not only of medical but of special psychological, educational, and social resources. Learning may or may not be impaired. The diagnosis must be based upon a complete history and evaluation of the child and not solely on the presence of the required number of DSM-IV® characteristics.

Dextroamphetamine saccharate, amphetamine aspartate monohydrate, dextroamphetamine sulfate and amphetamine sulfate tablets are indicated as an integral part of a total treatment program for ADHD that may include other measures (psychological, educational, social) for patients with this syndrome. Drug treatment may not be indicated for all children with this syndrome. Stimulants are not intended for use in the child who exhibits symptoms secondary to environmental factors and/or other primary psychiatric disorders, including psychosis. Appropriate educational placement is essential and psychosocial intervention is often helpful. When remedial measures alone are insufficient, the decision to prescribe stimulant medication will depend upon the physician's assessment of the chronicity and severity of the child's symptoms.

The effectiveness of dextroamphetamine saccharate, amphetamine aspartate monohydrate, dextroamphetamine sulfate and amphetamine sulfate tablets for long-term use has not been systematically evaluated in controlled trials. Therefore, the physician who elects to use dextroamphetamine saccharate, amphetamine aspartate monohydrate, dextroamphetamine sulfate and amphetamine sulfate tablets for extended periods should periodically re-evaluate the long-term usefulness of the drug for the individual patient.