Cefoxitin And Dextrose

Cefoxitin And Dextrose Manufacturers

• B. Braun Medical Inc.
  

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  头孢辛蛋白和葡萄糖|B. Braun Medical Inc.

  

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  Cefoxitin for Injection and Dextrose Injection in the DUPLEX® Container is intended for intravenous use only.

  TREATMENT Adults

  通常的成人剂量范围为每六到八个小时1克至2克。剂量应取决于病因的敏感性，感染的严重程度和患者的状况（剂量指南请参见表3）。beplay体验

  If C. trachomatis is a suspected pathogen, appropriate anti-chlamydial coverage should be added, because cefoxitin sodium has no activity against this organism.

  Cefoxitin for Injection and Dextrose Injection may be used in patients with reduced renal function with the following dosage adjustments:

  In adults with renal insufficiency, an initial loading dose of 1 gram to 2 grams may be given. After a loading dose, the recommendations for maintenance dosage (Table 4) may be used as a guide.

  When only the serum creatinine level is available, the following formula (based on sex, weight, and age of the patient) may be used to convert this value into creatinine clearance. The serum creatinine should represent a steady state of renal function.

  男性：体重（kg）×（140-年龄）72×血清肌酐（mg/100 mL）女性：0.85×高于值

  In patients undergoing hemodialysis, the loading dose of 1 to 2 grams should be given after each hemodialysis, and the maintenance dose should be given as indicated in Table 4.

  Antibiotic therapy for group A beta-hemolytic streptococcal infections should be maintained for at least 10 days to guard against the risk of rheumatic fever or glomerulonephritis. In staphylococcal and other infections involving a collection of pus, surgical drainage should be carried out where indicated.

  小儿患者

  The recommended dosage in pediatric patients three months of age and older is 80 to 160 mg/kg of body weight per day divided into four to six equal doses. The higher dosages should be used for more severe or serious infections. The total daily dosage should not exceed 12 grams.

  At this time no recommendation is made for pediatric patients from birth to three months of age (see PRECAUTIONS).

  在儿科患者肾功能不全,the dosage and frequency of dosage should be modified consistent with the recommendations for adults (see Table 4).

  PREVENTION

  Effective prophylactic use depends on the time of administration. Cefoxitin for Injection and Dextrose Injection usually should be given one-half to one hour before the operation, which is sufficient time to achieve effective levels in the wound during the procedure. Prophylactic administration should usually be stopped within 24 hours since continuing administration of any antibiotic increases the possibility of adverse reactions but, in the majority of surgical procedures, does not reduce the incidence of subsequent infection.

  在未被污染的预防性使用gastrointestinal surgery, vaginal hysterectomy, or abdominal hysterectomy, the following doses are recommended:

  Adults

  2grams administered intravenously just prior to surgery (approximately one-half to one hour before the initial incision) followed by 2 grams every 6 hours after the first dose for no more than 24 hours.

  小儿患者（3个月以上）

  30to 40 mg/kg doses may be given at the times designated above.

  Cesarean section patients

  对于接受剖宫产的患者，脐带夹紧后立即静脉内服用2克剂量，或者在静脉内固定后，由2克固定固定后，将脐带夹紧，然后夹紧2克4和8小时，然后静脉注射2克4和8小时建议初始剂量后。（请参阅临床研究。）

  Table 3 - Guidelines for Dosage of Cefoxitin for Injection Type of Infection Daily Dosage Frequency and Route * Including patients in whom bacteremia is absent or unlikely. Uncomplicated forms*
  of infections such as
  pneumonia, urinary
  tract infection, cutaneous
  infection 3–4 grams 1 gram every 6–8 hours IV Moderately severe or
  严重感染6-8克每4小时1克
  or
  2grams every 6–8 hours IV Infections commonly
  needing antibiotics in
  higher dosage (e.g.,
  gas gangrene) 12 grams 2 grams every 4 hours
  or
  每6个小时3克iv表4-头孢辛蛋白的维持剂量用于肾功能降低肾功能肌酐清除率降低的成人
  (mL/min) Dose
  (grams) Frequency Mild impairment 50–30 1–2 every 8–12 hours Moderate impairment 29–10 1–2 every 12–24 hours Severe impairment 9–5 0.5–1 every 12–24 hours Essentially no function <5 0.5–1 every 24–48 hours ADMINISTRATION

  The intravenous route is preferable for patients with bacteremia, bacterial septicemia, or other severe or life-threatening infections, or for patients who may be poor risks because of lowered resistance resulting from such debilitating conditions as malnutrition, trauma, surgery, diabetes, heart failure, or malignancy, particularly if shock is present or impending.

  Cefoxitin for Injection and Dextrose Injection may be administered through the tubing system by which the patient may be receiving other intravenous solutions. However, during infusion of the solution containing Cefoxitin for Injection and Dextrose Injection, it is advisable to temporarily discontinue administration of any other solutions at the same site.

  头孢辛蛋白用于注射和葡萄糖注射的溶液，例如大多数β-内酰胺抗生素的溶液，不应将其添加到氨基糖苷溶液（例如，硫酸庆大霉素，硫酸甲状腺霉素，硫酸氨基氨基酸酯，硫酸氨基胺）中，因为潜在的相互作用是潜在的相互作用。然而，可以分别对同一患者分别给予注射和葡萄糖注射和氨基糖苷的头孢辛蛋白。

  CAUTION: Do not use plastic containers in series connections. Such use would result in air embolism due to residual air being drawn from the primary container before administration of the fluid from the secondary container is complete.

  nOTE: Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration.

  Duplex®药物输送系统用于避免无意激活的用途，Duplex®容器应保持在折叠位置，直到打算激活为止。

  Patient Labeling and Drug Powder/Diluent Inspection

  Apply patient-specific label on foil side of container. USE CARE to avoid activation. Do not cover any portion of foil strip with patient label. Unlatch side tab and unfold Duplex® Container. (See Diagram 1.)
  Visually inspect diluent chamber for particulate matter. Use only if container and seals are intact. To inspect the drug powder for foreign matter or discoloration, peel foil strip from drug chamber. (See Diagram 2.)
  Protect from light after removal of foil strip.

  note: If foil strip is removed, product must be used within 7 days, but not beyond the labeled expiration date.

  The product should be re-folded and the side tab latched until ready to activate.

  reconstitution (Activation)

  不要使用后直接由制冷存储, allow the product to equilibrate to room temperature before patient use. Unfold the DUPLEX® Container and point the set port in a downward direction. Starting at the hanger tab end, fold the DUPLEX® Container just below the diluent meniscus trapping all air above the fold. To activate, squeeze the folded diluent chamber until the seal between the diluent and powder opens, releasing diluent into the drug powder chamber. (See Diagram 3.)
  搅拌液 - 粉混合物，直到药粉完全溶解为止。

  注意：重建后（激活），如果在室温下存储，则必须在12小时内或在7天内存储在制冷中。

  Administration

  Visually inspect the reconstituted solution for particulate matter. Point the set port in a downwards direction. Starting at the hanger tab end, fold the DUPLEX® Container just below the solution meniscus trapping all air above the fold. Squeeze the folded DUPLEX® Container until the seal between reconstituted drug solution and set port opens, releasing liquid to set port. (See Diagram 4.)
  在附加IV集之前，请牢固地挤压容器，检查是否有微小的泄漏。如果发现泄漏，则丢弃容器和解决方案，因为无菌性可能会受到损害。使用无菌技术，将箔纸从设定的端口覆盖并连接无菌给药组。（请参阅图5。）
  请参阅行政集合随附的说明。

  Precautions

  As with other cephalosporins, reconstituted Cefoxitin for Injection and Dextrose Injection tends to darken depending on storage conditions, within the stated recommendations. However, product potency is not adversely affected. Use only if prepared solution is clear and free from particulate matter. Do not use in series connection. Do not introduce additives into the DUPLEX® Container. Do not freeze.

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